Mechanistic Study of Diketopiperazine Formation during Solid-Phase Peptide Synthesis of Tirzepatide
Author:
Affiliation:
1. Synthetic Molecule Design and Development, Eli Lilly and Company, Indianapolis, Indiana46285, United States
2. Synthetic Molecule Design & Development, Eli Lilly Services India Pvt. Ltd., Bengaluru560103, India
Publisher
American Chemical Society (ACS)
Subject
General Chemical Engineering,General Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acsomega.2c05915
Reference39 articles.
1. Kilogram-Scale GMP Manufacture of Tirzepatide Using a Hybrid SPPS/LPPS Approach with Continuous Manufacturing
2. Johnson, M. D.; Kopach, M. E.; Webster, L. P.Three resin reactors in series peptide synthesizerWO 202115844 A2, 2021-08-12.
3. Acetylation an artefact in solid phase peptide synthesis. A mass spectrometrical investigation
4. Use of BOP reagent for the suppression of diketopiperazine formation in boc/bzl solid-phase peptide synthesis
5. Sustainable, cost-efficient manufacturing of therapeutic peptides using chemo-enzymatic peptide synthesis (CEPS)
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