Kilogram-Scale GMP Manufacture of Tirzepatide Using a Hybrid SPPS/LPPS Approach with Continuous Manufacturing-Reference-Cited by-同舟云学术

Kilogram-Scale GMP Manufacture of Tirzepatide Using a Hybrid SPPS/LPPS Approach with Continuous Manufacturing

Published:2021-06-17 Issue:7 Volume:25 Page:1628-1636
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Frederick Michael O.¹^ORCID,Boyse Raymond A.²,Braden Timothy M.¹,Calvin Joel R.¹,Campbell Bradley M.¹,Changi Shujauddin M.¹,Coffin Stephanie R.³,Condon Carmel²,Gowran Olivia⁴,McClary Groh Jennifer¹,Groskreutz Stephen R.¹,Harms Zachary D.¹^ORCID,Humenik Ashley A.²,Kallman Neil J.¹,Klitzing Nicholas D.¹,Kopach Michael E.¹,Kretsinger Juliana K.⁵,Lambertus Gordon R.¹,Lampert Jeffrey T.⁶,Maguire Laura M.²,Moynihan Humphrey A.²,Mullane Nessa S.²,Murphy John D.⁴,O’Mahony Marie E.²,Richey Rachel N.¹,Seibert Kevin D.¹,Spencer Richard D.²,Strege Mark A.¹,Tandogan Nil¹,Torres Torres Frank L.⁷,Tsukanov Sergey V.¹^ORCID,Xia Han¹^ORCID

Affiliation:

1. Synthetic Molecule Design and Development, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States

2. Technical Services/Manufacturing Services, Eli Lilly Kinsale Limited, Dunderrow, Kinsale P17 NY71, Co. Cork, Ireland

3. Commercialization Technical Center, Eli Lilly and Company, Indianapolis, Indiana 46285, United States

4. Quality Control Laboratories, Eli Lilly Kinsale Limited, Dunderrow, Kinsale P17 NY71, Co. Cork, Ireland

5. Bioproduct Research and Development, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States

6. Technical Services/Manufacturing Services, Eli Lilly and Company, Indianapolis, Indiana 46285, United States

7. Engineering Tech Center, Eli Lilly and Company, Indianapolis, Indiana 46285, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.1c00108

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2. The Current State of Peptide Drug Discovery: Back to the Future?

Dual GIP–GLP1-Receptor Agonists In The Treatment Of Type 2 Diabetes: A Short Review On Emerging Data And Therapeutic Potential

4. Efficacy and safety of LY3298176, a novel dual GIP and GLP-1 receptor agonist, in patients with type 2 diabetes: a randomised, placebo-controlled and active comparator-controlled phase 2 trial

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