Low pKa of Lys promotes glycation at one complementarity-determining region of a bispecific antibody

Author:

Xu Xiaobin,O'Callaghan Jessica Ann,Guarnero Zachary,Qiu Haibo,Li Ning,Potocky Terra,Kamen Douglas E.,Graham Kenneth S.,Shameem Mohammed,Yang Teng-ChiehORCID

Publisher

Elsevier BV

Subject

Biophysics

Reference36 articles.

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3. The principal site of nonenzymatic glycosylation of human serum albumin in vivo;Garlick;J. Biol. Chem.,1983

4. A perspective on the Maillard reaction and the analysis of protein glycation by mass spectrometry: probing the pathogenesis of chronic disease;Zhang;J. Proteome Res.,2009

5. Glycosylated minor components of human adult hemoglobin. Purification, identification, and partial structural analysis;McDonald;J. Biol. Chem.,1978

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