Improvement of the Cramer classification for oral exposure using the database TTC RepDose – A strategy description

Author:

Tluczkiewicz I.,Buist H.E.,Martin M.T.,Mangelsdorf I.,Escher S.E.

Publisher

Elsevier BV

Subject

Toxicology,General Medicine

Reference19 articles.

1. Barlow, S., 2005. Threshold of toxicological concern (TTC) – a tool for assessing substances of unknown toxicity present at low levels in the diet. In: International Life Science Institute Europe Concise Monograph Series. ILSI Europe a.i.s.b.l., Brussels, 1–32.

2. RepDose: a database on repeated dose toxicity studies of commercial chemicals – a multifunctional tool;Bitsch;Regul. Toxicol. Pharmacol.,2006

3. Improving synthetic hindered phenol antioxidants: learning from vitamin E;Breese;Polym. Degrad. Stability,2000

4. Estimation of toxic hazard–a decision tree approach;Cramer;Food Cosmet. Toxicol.,1978

5. ECHA 2008, Guidance on information requirements and chemical safety assessment. Chapter R.5/R.8: Adaptation of information requirements/ Characterisation of dose [concentration]-response for human health. European Chemicals Agency.

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