The SGLT2 inhibitor Empagliflozin attenuates interleukin-17A-induced human aortic smooth muscle cell proliferation and migration by targeting TRAF3IP2/ROS/NLRP3/Caspase-1-dependent IL-1β and IL-18 secretion-Reference-Cited by-同舟云学术

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The SGLT2 inhibitor Empagliflozin attenuates interleukin-17A-induced human aortic smooth muscle cell proliferation and migration by targeting TRAF3IP2/ROS/NLRP3/Caspase-1-dependent IL-1β and IL-18 secretion

Published:2021-01 Issue: Volume:77 Page:109825
ISSN:0898-6568
Container-title:Cellular Signalling
language:en
Short-container-title:Cellular Signalling

Author:

Sukhanov Sergiy,Higashi Yusuke,Yoshida Tadashi,Mummidi Srinivas,Aroor Annayya R.,Jeffrey Russell Jacob,Bender Shawn B.,DeMarco Vincent G.,Chandrasekar Bysani

Funder

U.S. Department of Veterans Affairs

Office of Research and Development

Research Career Scientist Award

NIH

American Heart Association

Medical Research Foundation

Publisher

Elsevier BV

Subject

Cell Biology

Reference82 articles.

1. Resveratrol inhibits high glucose-induced PI3K/Akt/ERK-dependent interleukin-17 expression in primary mouse cardiac fibroblasts;Venkatachalam;Am. J. Physiol. Heart Circ. Physiol.,2008

2. Augmented Th17 differentiation in Trim21 deficiency promotes a stable phenotype of atherosclerotic plaques with high collagen content;Brauner;Cardiovasc. Res.,2018

3. Expression of IL-17A in human atherosclerotic lesions is associated with increased inflammation and plaque vulnerability;Erbel;Basic Res. Cardiol.,2011

4. Aggravated atherosclerosis and vascular inflammation with reduced kidney function depend on Interleukin-17 receptor a and are normalized by inhibition of interleukin-17A;Nordlohne;JACC. Basic to translational science,2018

5. RECK suppresses interleukin-17/TRAF3IP2-mediated MMP-13 activation and human aortic smooth muscle cell migration and proliferation;Mummidi;J. Cell. Physiol.,2019

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