Chronic intermittent hypoxia facilitates the development of angiotensin II-induced abdominal aortic aneurysm in male mice-Reference-Cited by-同舟云学术

Chronic intermittent hypoxia facilitates the development of angiotensin II-induced abdominal aortic aneurysm in male mice

Published:2024-09-01 Issue:3 Volume:137 Page:527-539
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Sharma Neekun¹²³^ORCID,Khalyfa Abdelnaby⁴,Cai Dunpeng⁵,Morales-Quinones Mariana¹^ORCID,Soares Rogerio N.¹^ORCID,Higashi Yusuke⁶^ORCID,Chen Shiyou⁵⁷,Gozal David⁴,Padilla Jaume¹⁷⁸^ORCID,Manrique-Acevedo Camila¹³⁷^ORCID,Chandrasekar Bysani⁷⁹,Martinez-Lemus Luis A.¹²¹⁰^ORCID

Affiliation:

1. NextGen Precision Health, University of Missouri, Columbia, Missouri, United States

2. Department of Medicine, Center for Precision Medicine, University of Missouri, Columbia, Missouri, United States

3. Division of Endocrinology and Metabolism, Department of Medicine, University of Missouri, Columbia, Missouri, United States

4. Department of Child Health and the Child Health Research Institute, School of Medicine, University of Missouri, Columbia, Missouri, United States

5. Department of Surgery, University of Missouri, Columbia, Missouri, United States

6. John W. Deming Department of Medicine, Tulane University, New Orleans, Louisiana, United States

7. Harry S. Truman Memorial Veterans’ Hospital, Columbia, Missouri, United States

8. Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, United States

9. Division of Cadiovascular Medicine, Department of Medicine, University of Missouri, Columbia, Missouri, United States

10. Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri, United States

Abstract

IH facilitates Ang II-induced abdominal aortic diameter expansion and AAA development in C57BL/6J male mice. IH upregulates the expression of specific MMPs such as MMP8, MMP12, and ADAM17. IH directly suppresses RECK expression and increases MMPs activity in SMCs. Human AAA tissues exhibit a downregulation of RECK and an upregulation of ADAM17 and MMPs.

Funder

HHS | National Institutes of Health

U.S. Department of Veterans Affairs

University of Missouri

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00842.2023

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