Bioavailability of amoxicillin and clavulanic acid from extended release tablets depends on intragastric tablet deposition and gastric emptying

Author:

Weitschies W.,Friedrich C.,Wedemeyer R.S.,Schmidtmann M.,Kosch O.,Kinzig M.,Trahms L.,Sörgel F.,Siegmund W.,Horkovics-Kovats S.,Schwarz F.,Raneburger J.,Mönnikes H.

Publisher

Elsevier BV

Subject

Pharmaceutical Science,General Medicine,Biotechnology

Reference24 articles.

1. Influence of physicochemical properties on dissolution of drugs in the gastrointestinal tract;Horter;Adv. Drug Deliv. Rev.,2001

2. Intestinal fluid volumes and transit of dosage forms as assessed by magnetic resonance imaging;Schiller;Aliment. Pharmacol. Ther.,2005

3. Comparison of the mechanical destructive force in the small intestine of dog and human;Kamba;Int. J. Pharm.,2002

4. Absorption pattern of trospium chloride along the human gastrointestinal tract assessed using local enteral administration;Schröder;Int. J. Clin. Pharmacol. Ther.,2004

5. U.S. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER), Guidance for Industry. Food-Effect Bioavailability and Fed Bioequivalence Studies, December 2002.

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