CHO cathepsin B identified as the protease responsible for a target bispecific antibody fragmentation
Author:
Publisher
Elsevier BV
Subject
Biotechnology
Reference12 articles.
1. Degradation of an Fc-fusion recombinant protein by host cell proteases: identification of a CHO cathepsin D protease;Robert;Biotechnol. Bioeng.,2009
2. Characterization of the proteases involved in the N-terminal clipping of glucagon-like-peptide-1-antibody fusion proteins;Dorai;Biotechnol. Prog.,2011
3. Fragmentation of a highly purified monoclonal antibody attributed to residual CHO cell protease activity;Gao;Biotechnol. Bioeng.,2011
4. Trace levels of the CHO host cell protease cathepsin D caused particle formation in a monoclonal antibody product;Bee;Biotechnol. Prog.,2015
5. Characterization of a cathepsin D protease from CHO cell-free medium and mitigation of its impact on the stability of a recombinant therapeutic protein;Lim;Biotechnol. Prog.,2018
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2. Impact of fed-batch process intensification on the productivity and product quality of two CHO cell lines expressing unique novel molecular format proteins;Bioprocess and Biosystems Engineering;2024-04-23
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