Characterization of a cathepsin D protease from CHO cell-free medium and mitigation of its impact on the stability of a recombinant therapeutic protein-Reference-Cited by-同舟云学术

Characterization of a cathepsin D protease from CHO cell-free medium and mitigation of its impact on the stability of a recombinant therapeutic protein

Published:2017-08-09 Issue:1 Volume:34 Page:120-129
ISSN:8756-7938
Container-title:Biotechnology Progress
language:en
Short-container-title:Biotechnol Progress

Author:

Lim Amareth¹^ORCID,Doyle Brandon L.¹,Kelly Gerard M.¹,Reed-Bogan Angelia M.¹,Breen Lawrence H.¹,Shamlou Parviz A.¹,Lambooy Peter K.¹

Affiliation:

1. Bioproduct Research and Development, Eli Lilly and Company; Indianapolis IN 46285

Publisher

Wiley

Subject

Biotechnology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/btpr.2530/fullpdf

Reference12 articles.

1. Cell culture processes for monoclonal antibody production;Li;mAbs.,2010

2. Of [Hamsters] and men: a new perspective on host cell proteins;Gutiérrez;Hum Vaccin Immunother.,2012

3. Degradation of an Fc-fusion recombinant protein by host cell proteases: identification of a CHO cathepsin D protease;Robert;Biotechnol Bioeng.,2009

4. Characterization of the proteases involved in the N-terminal clipping of glucagon-like-peptide-1-antibody fusion proteins;Dorai;Biotechnol Prog.,2011

5. Fragmentation of a highly purified monoclonal antibody attributed to residual CHO cell protease activity;Gao;Biotechnol Bioeng.,2011

Cited by 31 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Identification of Acyl-Protein Thioesterase-1 as a Polysorbate-Degrading Host Cell Protein in a Monoclonal Antibody Formulation Using Activity-Based Protein Profiling;Journal of Pharmaceutical Sciences;2024-08

2. Expression in CHO cells of a bacterial biosynthetic pathway producing a small non-ribosomal peptide aldehyde prevents proteolysis of recombinant proteins;Metabolic Engineering;2024-03

3. Recombinant therapeutic proteins degradation and overcoming strategies in CHO cells;Applied Microbiology and Biotechnology;2024-01-29

4. Application of Formulation Principles to Stability Issues Encountered During Processing, Manufacturing, and Storage of Drug Substance and Drug Product Protein Therapeutics;Journal of Pharmaceutical Sciences;2023-11

5. Development of Coulometric Mass Spectrometry for Absolute Chemical Quantitation;Encyclopedia of Analytical Chemistry;2023-10-30