Removing half antibody byproduct by Protein A chromatography during the purification of a bispecific antibody
Author:
Publisher
Elsevier BV
Subject
Biotechnology
Reference5 articles.
1. Engineering bispecific antibodies with defined chain pairing;Krah;Nat. Biotechnol.,2017
2. A brief introduction of IgG-like bispecific antibody purification: methods for removing product-related impurities;Li;Protein Expr. Purif.,2019
3. Development of purification processes for fully human bispecific antibodies based upon modification of protein A binding avidity;Tustian;mAbs,2016
4. Removal of half antibody, hole-hole homodimer and aggregates during bispecific antibody purification using MMC ImpRes mixed-mode chromatography;Tang;Protein Expr. Purif.,2020
5. A method for improving protein A chromatography’s aggregate removal capability;Zhang;Protein Expr. Purif.,2019
Cited by 10 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Resin and loading condition screening for effective and robust byproducts removal by anion exchange chromatography: A case study;Protein Expression and Purification;2023-10
2. Assessing four subdomain-specific affinity resins’ capability to separate half-antibody from intact bispecific antibody;Protein Expression and Purification;2022-10
3. Effective flow-through polishing strategies for knob-into-hole bispecific antibodies;Bioresources and Bioprocessing;2022-09-14
4. The manufacturing considerations of bispecific antibodies;Expert Opinion on Biological Therapy;2022-07-06
5. Excellent removal of knob-into-hole bispecific antibody byproducts and impurities in a single-capture chromatography;Bioresources and Bioprocessing;2022-07-04
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