Inhibitors of 17β-hydroxysteroid dehydrogenase type 1, 2 and 14: Structures, biological activities and future challenges
Author:
Funder
Deutsche Forschungsgemeinschaft
Publisher
Elsevier BV
Subject
Endocrinology,Molecular Biology,Biochemistry
Reference114 articles.
1. Inhibition of 17β-HSD1: SAR of bicyclic substituted hydroxyphenylmethanones and discovery of new potent inhibitors with thioether linker;Abdelsamie;Eur. J. Med. Chem.,2014
2. Towards the evaluation in an animal disease model: fluorinated 17β-HSD1 inhibitors showing strong activity towards both the human and the rat enzyme;Abdelsamie;Eur. J. Med. Chem.,2015
3. Treatment of estrogen-dependent diseases: design, synthesis and profiling of a selective 17β-HSD1 inhibitor with sub-nanomolar IC 50 for a proof-of-principle study;Abdelsamie;Eur. J. Med. Chem.,2017
4. The role of the heterocycle in bis(hydroxyphenyl)triazoles for inhibition of 17β-Hydroxysteroid Dehydrogenase (17β-HSD) type 1 and type 2;Al-Soud;Mol. Cell. Endocrinol.,2009
5. Synthesis and biological evaluation of phenyl substituted 1H-1,2,4-Triazoles as non-steroidal inhibitors of 17β-hydroxysteroid dehydrogenase type 2;Al-Soud;Arch. Pharm.,2012
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