Structure-guided optimization of 3-hydroxybenzoisoxazole derivatives as inhibitors of Aldo-keto reductase 1C3 (AKR1C3) to target prostate cancer-Reference-Cited by-同舟云学术

Structure-guided optimization of 3-hydroxybenzoisoxazole derivatives as inhibitors of Aldo-keto reductase 1C3 (AKR1C3) to target prostate cancer

Published:2024-03 Issue: Volume:268 Page:116193
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Pippione Agnese Chiara,Kovachka Sandra,Vigato Chiara,Bertarini Laura,Mannella Iole,Sainas Stefano,Rolando Barbara,Denasio Enrica,Piercy-Mycock Helen,Romalho Linda,Salladini Edoardo,Adinolfi Salvatore,Zonari Daniele,Peraldo-Neia Caterina,Chiorino Giovanna,Passoni Alice,Mirza Osman Asghar,Frydenvang Karla,Pors Klaus,Lolli Marco Lucio,Spyrakis Francesca,Oliaro-Bosso Simonetta,Boschi Donatella^ORCID

Funder

Fondazione CRT

University of Turin

Publisher

Elsevier BV

Reference70 articles.

1. Aldo-keto reductase AKR1C1-AKR1C4: functions, regulation, and intervention for anti-cancer therapy;Zeng;Front. Pharmacol.,2017

2. AKR1C3 (type 5 17beta-hydroxysteroid dehydrogenase/prostaglandin F synthase): roles in malignancy and endocrine disorders;Penning;Mol. Cell. Endocrinol.,2019

3. A novel selective AKR1C3-activated prodrug AST-3424/OBI-3424 exhibits broad anti-tumor activity;Meng;Am. J. Cancer Res.,2021

4. An AKR1C3-specific prodrug with potent anti-tumor activities against T-ALL;Wang;Leuk. Lymphoma,2020

5. OBI-3424, a novel AKR1C3-activated prodrug, exhibits potent efficacy against preclinical models of T-ALL;Evans;Clin. Cancer Res.,2019

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Aldo-keto reductase (AKR) superfamily website and database: An update;Chemico-Biological Interactions;2024-08

2. AI Based Discovery of a New AKR1C3 Inhibitor for Anticancer Applications;ACS Medicinal Chemistry Letters;2024-07-03