Minor chemical modifications of the aminosteroid derivative RM-581 lead to major impact on its anticancer activity, metabolic stability and aqueous solubility-Reference-Cited by-同舟云学术

Minor chemical modifications of the aminosteroid derivative RM-581 lead to major impact on its anticancer activity, metabolic stability and aqueous solubility

Published:2020-02 Issue: Volume:188 Page:111990
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Maltais René^ORCID,Perreault Martin,Roy Jenny,Poirier Donald^ORCID

Funder

Canadian Institutes of Health Research

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference53 articles.

1. The aminosteroid derivative RM-133 shows in vitro and in vivo antitumor activity in human ovarian and pancreatic cancers;Kenmogne;PLoS One,2015

2. Chemical synthesis, NMR analysis and evaluation on a cancer xenograft model (HL-60) of the aminosteroid derivative RM-133;Maltais;Steroids,2014

3. Solid-phase chemical synthesis and in vitro biological evaluation of novel 2beta-piperazino-(20R)-5alpha-pregnane-3alpha,20-diol N-derivatives as anti-leukemic agents;Jegham;Steroids,2012

4. New diethylsilylacetylenic linker for parallel solid-phase synthesis of libraries of hydroxy acetylenic steroid derivatives with improved metabolic stability;Talbot;ACS Comb. Sci.,2012

5. Biological evaluation of a new family of aminosteroids that display a selective toxicity for various malignant cell lines;Jegham;Anti Cancer Drugs,2012

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4. Chemical synthesis, NMR characterization, and anticancer activity of androstene derivatives with a C17-side chain;Steroids;2022-10

5. 16-Picolyl-androsterone derivative exhibits potent 17β-HSD3 inhibitory activity, improved metabolic stability and cytotoxic effect on various cancer cells: Synthesis, homology modeling and docking studies;The Journal of Steroid Biochemistry and Molecular Biology;2021-06