Advances in the studies of roles of Rho/Rho-kinase in diseases and the development of its inhibitors

Author:

Guan Ronggui,Xu Xiaoyu,Chen Meihui,Hu Haiyan,Ge Hu,Wen Shijun,Zhou Shiyou,Pi Rongbiao

Funder

National Natural Science Foundation of China/RGC Hong Kong Joint Research Scheme

Guangdong Provincial International Cooperation Project of Science & Technology

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference71 articles.

1. Rho-kinase: important new therapeutic target in cardiovascular diseases;Satoh;Am. J. Physiol. Heart Circ. Physiol.,2011

2. Rho/ROCK pathway and neural regeneration: a potential therapeutic target for central nervous system and optic nerve damage;Tan;Int. J. Ophthalmol.,2011

3. Rho kinase, a promising drug target for neurological disorders;Mueller;Nat. Rev. Drug Discov.,2005

4. Rho GTPase regulation by miRNAs and covalent modifications;Liu;Trends Cell Biol.,2012

5. Elaborate ligand-based modeling reveal new submicromolar Rho kinase inhibitors;Shahin;J. Comput. Aided Mol. Des.,2012

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