Intracellular signaling pathways of muscarinic acetylcholine receptor-mediated detrusor muscle contractions-Reference-Cited by-同舟云学术

Intracellular signaling pathways of muscarinic acetylcholine receptor-mediated detrusor muscle contractions

Published:2023-11-01 Issue:5 Volume:325 Page:F618-F628
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Balla Helga¹^ORCID,Borsodi Kinga¹^ORCID,Őrsy Petra¹,Horváth Béla¹,Molnár Péter József¹²^ORCID,Lénárt Ádám¹^ORCID,Kosztelnik Mónika¹³^ORCID,Ruisanchez Éva¹³^ORCID,Wess Jürgen⁴^ORCID,Offermanns Stefan⁵^ORCID,Nyirády Péter²^ORCID,Benyó Zoltán¹³^ORCID

Affiliation:

1. Institute of Translational Medicine, Semmelweis University, Budapest, Hungary

2. Department of Urology, Semmelweis University, Budapest, Hungary

3. HUN-REN-SE Cerebrosvascular and Neurodegenerative Disease Research Group, Budapest, Hungary

4. Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, United States

5. Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany

Abstract

Muscarinic acetylcholine receptors are of utmost importance in physiological regulation of micturition and also in the development of voiding disorders. We demonstrate that the RhoA-Rho-associated kinase (ROCK) pathway plays a crucial role in contractions induced by cholinergic stimulation in detrusor muscle. Activation of RhoA is mediated by both M2 and M3 receptors as well as by Gi but not Gq/11 proteins. The Gi-RhoA-ROCK pathway may provide a novel therapeutic target for overactive voiding disorders.

Funder

Gedeon Richter Plc Talent Foundation

Innovációs és Technológiai Minisztérium

NKFI | National Research, Development and Innovation Office

Semmelweis Egyetem

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00261.2022

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