Identification and biochemical characterization of DC07090 as a novel potent small molecule inhibitor against human enterovirus 71 3C protease by structure-based virtual screening

Author:

Ma Guang-Hui,Ye Yan,Zhang Dan,Xu Xin,Si Pei,Peng Jian-Long,Xiao Yong-Long,Cao Rui-Yuan,Yin Yu-Ling,Chen Jing,Zhao Lin-Xiang,Zhou Yu,Zhong Wu,Liu Hong,Luo Xiao-Min,Chen Li-Li,Shen Xu

Funder

National Natural Science Foundation of China

State Key Laboratory of Natural and Biomimetic Drugs

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference43 articles.

1. Fragment-wise design of inhibitors to 3C proteinase from enterovirus 71;Wu;Biochim. Biophys. Acta,2016

2. Peptidyl aldehyde NK-1.8k suppresses enterovirus 71 and enterovirus 68 infection by targeting protease 3C;Wang;Antimicrob. Agents Chemother.,2015

3. Atypical hand-foot-and-mouth disease associated with coxsackievirus A6 infection;Lott;J. Am. Acad. Dermatol,2013

4. Peptidomimetic ethyl propenoate covalent inhibitors of the enterovirus 71 3C protease: a P2-P4 study;Ang;J. Enzyme Inhib. Med. Chem.,2016

5. Risk factors for severe enteroviral infections in children;Owatanapanich;J. Med. Assoc. Thai,2016

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