Affiliation:
1. Key Laboratory of Green Chemical Engineering Process of Ministry of Education School of Chemical Engineering and Pharmacy Wuhan Institute of Technology Wuhan 430205 P. R. China
2. School of Pharmacy Xianning Medical College Hubei University of Science and Technology Xianning 437100 P. R. China
Abstract
AbstractThe 3C protease (3C Pro) plays a significant role in the life cycle of picornaviruses from replication to translation, making it an attractive target for structure‐based design of drugs against picornaviruses. The structurally related 3C‐like protease (3CL Pro) is an important protein involved in the replication of coronaviruses. With the emergence of COVID‐19 and consequent intensive research into 3CL Pro, development of 3CL Pro inhibitors has emerged as a popular topic. This article compares the similarities of the target pockets of various 3C and 3CL Pros from numerous pathogenic viruses. This article also reports several types of 3C Pro inhibitors that are currently undergoing extensive studies and introduces various structural modifications of 3C Pro inhibitors to provide a reference for the development of new and more effective inhibitors of 3C Pro and 3CL Pro.
Funder
Wuhan Institute of Technology
Subject
Molecular Biology,Molecular Medicine,General Chemistry,Biochemistry,General Medicine,Bioengineering