An Ancient, Unified Mechanism for Metformin Growth Inhibition in C. elegans and Cancer

Author:

Wu Lianfeng,Zhou Ben,Oshiro-Rapley Noriko,Li Man,Paulo Joao A.,Webster Christopher M.,Mou Fan,Kacergis Michael C.,Talkowski Michael E.,Carr Christopher E.,Gygi Steven P.,Zheng Bin,Soukas Alexander A.

Funder

NIH

Broad Institute SPARC Grant

NORC of Harvard

Boston Area DERC

Publisher

Elsevier BV

Subject

General Biochemistry, Genetics and Molecular Biology

Reference48 articles.

1. The expanding relevance of nuclear mTOR in carcinogenesis;Back;Cell Cycle,2011

2. Metformin as a Tool to Target Aging;Barzilai;Cell Metab.,2016

3. Where is mTOR and what is it doing there?;Betz;J. Cell Biol.,2013

4. Variants in ACAD10 are associated with type 2 diabetes, insulin resistance and lipid oxidation in Pima Indians;Bian;Diabetologia,2010

5. The genetics of Caenorhabditis elegans;Brenner;Genetics,1974

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