Optimization of solid-phase extraction and liquid chromatography-tandem mass spectrometry for simultaneous determination of capilliposide B and its active metabolite in rat urine and feces: Overcoming nonspecific binding

Author:

Cheng Zhongzhe,Zhou Xing,Li Wenyi,Hu Bingying,Zhang Yang,Xu Yong,Zhang Lin,Jiang Hongliang

Funder

National Science and Technology Major Project of China

Program for Zhejiang Leading Team of S&T Innovation

Project of Shandong Province Higher Educational Science and Technology Program

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Spectroscopy,Drug Discovery,Pharmaceutical Science,Analytical Chemistry

Reference12 articles.

1. Three novel triterpenoid saponins from Lysimachia capillipes and their cytotoxic activities;Tian;Chem. Pharm. Bull.,2006

2. Capilliposide isolated from lysimachia capillipes hemsl. Induces ROS generation, cell cycle arrest, and apoptosis in human nonsmall cell lung cancer cell lines;Fei;eCAM,2014

3. Experimental studies on anti-tumor effects of Capilliposide;Xu;Chin. Pharm. Bull.,2012

4. Simultaneous determination of capilliposide B and capilliposide C in rat plasma by LC–MS/MS and its application to a PK study;Cheng;Bioanalysis,2014

5. Cell-based assays in combination with ultra-high performance liquid chromatography-quadrupole time of flight tandem mass spectrometry for screening bioactive capilliposide C metabolites generated by rat intestinal microflora;Zhongzhe;J. Pharm. Biomed. Anal.,2015

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