Metabolic fate of combretastatin A-1: LC-DAD-MS/MS investigation and biological evaluation of its reactive metabolites-Reference-Cited by-同舟云学术

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Metabolic fate of combretastatin A-1: LC-DAD-MS/MS investigation and biological evaluation of its reactive metabolites

Published:2013-05 Issue: Volume:78-79 Page:233-242
ISSN:0731-7085
Container-title:Journal of Pharmaceutical and Biomedical Analysis
language:en
Short-container-title:Journal of Pharmaceutical and Biomedical Analysis

Author:

Aprile Silvio,Zaninetti Roberta,Del Grosso Erika,Genazzani Armando A.,Grosa Giorgio

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Spectroscopy,Drug Discovery,Pharmaceutical Science,Analytical Chemistry

Reference25 articles.

1. Disrupting tumour blood vessels;Tozer;Nat. Rev. Cancer,2005

2. Antineoplastic agent 124. Isolation, structure and synthesis of combretastatin-A1 and combretastatin-B1, potent new inhibitors of microtubule assembly, derived from Combretum caffrum;Pettit;J. Nat. Prod.,1987

3. Antineoplastic agents. 552. Oxidation of combretastatin A-1: trapping the o-quinone intermediate considered the metabolic product of the corresponding phosphate prodrug;Pettit;J. Nat. Prod.,2008

4. ClinicalTrials.gov. Available from: http://www.clinicaltrials.gov/.

5. Oxidative metabolism of combretastatin A-1 produces quinone intermediates with the potential to bind to nucleophiles and to enhance oxidative stress via free radicals;Folkes;Chem. Res. Toxicol.,2007

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3. β-Lactam analogues of combretastatin A-4 prevent metabolic inactivation by glucuronidation in chemoresistant HT-29 colon cancer cells;European Journal of Medicinal Chemistry;2017-04

4. Direct arterial injection of hyperpolarized 13 C-labeled substrates into rat tumors for rapid MR detection of metabolism with minimal substrate dilution;Magnetic Resonance in Medicine;2017-02-12

5. Marking of metabolites in the diagnostics of metabolic diseases and in the investigation of xenobiotics metabolism using NMR spectroscopy;Journal of Pharmaceutical and Biomedical Analysis;2016-10

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