Identification of bicyclol metabolites in rat plasma, urine and feces by UPLC-Q-TOF-MS/MS and evaluation of the efficacy and safety of these metabolites based on network pharmacology and molecular docking combined with toxicity prediction-Reference-Cited by-同舟云学术

Identification of bicyclol metabolites in rat plasma, urine and feces by UPLC-Q-TOF-MS/MS and evaluation of the efficacy and safety of these metabolites based on network pharmacology and molecular docking combined with toxicity prediction

Published:2022-10 Issue: Volume:220 Page:114947
ISSN:0731-7085
Container-title:Journal of Pharmaceutical and Biomedical Analysis
language:en
Short-container-title:Journal of Pharmaceutical and Biomedical Analysis

Author:

Huang Xucong,Jia Mengqi,Liu Yanchao,Wang Shuowen,Tang Yuanjun,Li Xiaojing,Jiang Xinhui,Wu Zhenghua,Lou Yuefen,Fan Guorong

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Spectroscopy,Drug Discovery,Pharmaceutical Science,Analytical Chemistry

Reference33 articles.

1. Prediction and mechanistic analysis of drug-induced liver injury (DILI) based on chemical structure;Liu;Biol. Direct,2021

2. Chronic drug-induced liver injury: updates and future challenges;Wang;Front. Pharmacol.,2021

3. Clinical management of patients with drug-induced liver injury (DILI), United European;Bjornsson;Gastroenterol. J.,2021

4. N. drug-induced liver injury, death and liver transplantation within 2 years of onset of drug-induced liver injury;Hayashi;Hepatology,2017

5. Incidence and etiology of drug-induced liver injury in mainland China;Shen;Gastroenterology,2019

Cited by 7 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Upregulation of Hepatic Glutathione S-Transferase Alpha 1 Ameliorates Metabolic Dysfunction-Associated Steatosis by Degrading Fatty Acid Binding Protein 1;International Journal of Molecular Sciences;2024-05-07

2. Characterization of the metabolic contributions of cytochrome P450 isoforms to bicyclol using the relative activity factor method;Journal of Asian Natural Products Research;2024-04-17

3. Simultaneous determination of bicyclol and its two active metabolites concentration in rat plasma and application for pharmacokinetics study of bicyclol and optimized bicyclol-nanoparticles;Arabian Journal of Chemistry;2023-12

4. Chemical components characterization and in vivo metabolites profiling of Lingbao Huxin Dan by gas chromatography‐mass spectrometry and ultra‐high‐performance liquid chromatography‐tandem quadrupole time‐of‐flight mass spectrometry;Journal of Separation Science;2023-11-27

5. Recycling preparative isolation of six bicyclol active metabolites from SD rat urine using macroporous resin, offline 2D LPLC/HPLC, and prep-HPLC combined with pharmacodynamic evaluation of two active metabolites;Arabian Journal of Chemistry;2023-10