Triazolopyrimidines Are Microtubule-Stabilizing Agents that Bind the Vinca Inhibitor Site of Tubulin

Author:

Sáez-Calvo Gonzalo,Sharma Ashwani,Balaguer Francisco de Asís,Barasoain Isabel,Rodríguez-Salarichs Javier,Olieric Natacha,Muñoz-Hernández Hugo,Berbís Manuel Álvaro,Wendeborn Sebastian,Peñalva Miguel Angel,Matesanz Ruth,Canales Ángeles,Prota Andrea Enrico,Jímenez-Barbero Jesús,Andreu José Manuel,Lamberth Clemens,Steinmetz Michel Olivier,Díaz José Fernando

Funder

AEI/FEDER

Ministerio de Economía y Competitividad

Swiss National Science Foundation

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,Molecular Medicine,Biochemistry

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5. Solution structure of Taxotere-induced microtubules to 3-nm resolution. The change in protofilament number is linked to the binding of the taxol side chain;Andreu;J. Biol. Chem.,1994

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