Antimicrobial evaluation of composite films based on polyvinyl alcohol/triazolopyrimidenes/selenium nanoparticles

Abstract

Background Using ultrasonic waves, a multi-component reaction of aminotriazole, carbonyl compounds and cyanoester derivatives, triazolopyrimidines are created with outstanding yields in a shorter amount of time. Selenium nanoparticles (SeNPs) with outstanding biological activity combined with triazolopyrimidine can imply promising materials for different biological applications. Objective Synthesis of triazolopyrimidine compounds conjugated with SeNPs and their incorporation into biodegradable polyvinyl alcohol for antimicrobial application were investigated. Methods The synthesized triazole derivatives were used in the synthesis of in situ SeNPs. The synthesized triazole derivatives and SeNPs were blended with polyvinyl alcohol (PVa) to prepare composite films. All synthesized compounds were confirmed using FT-IR, 1H-NMR, mass spectroscopy and elemental analysis. The prepared PVa composite films with nanoparticles were tested against Gram-positive (+ ve) and Gram-negative (−ve) bacteria. Results The treated PVA with the SeNPs showed high biological efficiency compared with PVA treated with triazole derivatives.