Modulation of taxane binding to tubulin curved and straight conformations by systematic 3′N modification provides for improved microtubule binding, persistent cytotoxicity and in vivo potency-Reference-Cited by-同舟云学术

Modulation of taxane binding to tubulin curved and straight conformations by systematic 3′N modification provides for improved microtubule binding, persistent cytotoxicity and in vivo potency

Published:2023-11 Issue: Volume:259 Page:115668
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Ma Yuntao,Josa-Prado Fernando,Essif Jacob Nathaniel,Liu Shuqi,Li Shuo,Lucena-Agell Daniel,Chan Peter YW.,Goossens Kenneth,Hortigüela Rafael,Matesanz Ruth,Wang Yingjie,Gago Federico,Wang Hongbo,Risinger April,Diaz J. Fernando,Fang Wei-Shuo^ORCID

Funder

NSFC

Chinese Academy of Medical Sciences & Peking Union Medical College State Key Laboratory of Bioactive Substance and Function of N

CIFMS

España Ministerio de Ciencia e Innovación

Youth Innovation Technology Project of Higher School in Shandong Province

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

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4. Fluoroindole chalcone analogues targeting the colchicine binding site of tubulin for colorectal oncotherapy;Liu;Eur. J. Med. Chem.,2023

5. Design, synthesis, and biological evaluation of diaryl heterocyclic derivatives targeting tubulin polymerization with potent anticancer activities;Li;Eur. J. Med. Chem.,2023