Try Me: Promiscuous Inhibitors Still Allow for Selective Targeted Protein Degradation
Author:
Publisher
Elsevier BV
Subject
Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,Molecular Medicine,Biochemistry
Reference13 articles.
1. Structure-guided development of affinity probes for tyrosine kinases using chemical genetics;Blair;Nat. Chem. Biol.,2007
2. Catalytic in vivo protein knockdown by small-molecule PROTACs;Bondeson;Nat. Chem. Biol.,2015
3. Lessons in PROTAC design from selective degradation with a promiscuous warhead;Bondeson;Cell Chem Biol,2018
4. Covalent lipid pocket ligands targeting p38α MAPK mutants;Bührmann;Angew. Chem. Int. Ed.,2017
5. The advantages of targeted protein degradation over inhibition: an RTK case study;Burslem;Cell Chem Biol,2018
Cited by 7 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Exploration of Hydrazide-Based HDAC8 PROTACs for the Treatment of Hematological Malignancies and Solid Tumors;Journal of Medicinal Chemistry;2024-08-01
2. Synthetic approaches to constructing proteolysis targeting chimeras (PROTACs);Mendeleev Communications;2022-07
3. The importance of cellular degradation kinetics for understanding mechanisms in targeted protein degradation;Chemical Society Reviews;2022
4. PTPs: Degrading the Undruggable;Journal of Medicinal Chemistry;2020-07-02
5. Induced degradation of protein kinases by bifunctional small molecules: a next-generation strategy;Expert Opinion on Drug Discovery;2019-09-12
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3