Bundling of mRNA strands inside polyion complexes improves mRNA delivery efficiency in vitro and in vivo

Author:

Koji Kyoko,Yoshinaga Naoto,Mochida Yuki,Hong Taehun,Miyazaki Takuya,Kataoka Kazunori,Osada Kensuke,Cabral Horacio,Uchida Satoshi

Funder

Ministry of Education, Culture, Sports, Science and Technology

MEXT

Research and Development of Core Technologies for Gene and Cell Therapy

Project for Cancer Research And Therapeutic Evolution

Japan Agency for Medical Research and Development

AMED

Publisher

Elsevier BV

Subject

Mechanics of Materials,Biomaterials,Biophysics,Ceramics and Composites,Bioengineering

Reference36 articles.

1. Tools for translation: non-viral materials for therapeutic mRNA delivery;Hajj;Nature Reviews Materials,2017

2. mRNA therapeutics deliver a hopeful message;Zhong;Nano Today,2018

3. Design concepts of polyplex micelles for in vivo therapeutic delivery of plasmid DNA and messenger RNA;Uchida;J. Biomed. Mater. Res. A,2019

4. Emerging concepts of nanobiotechnology in mRNA delivery;Wang;Angew Chem. Int. Ed. Engl.,2020

5. Serum nuclease susceptibility of mRNA cargo in condensed polyplexes;Yen;Mol. Pharm.,2018

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