Serum Nuclease Susceptibility of mRNA Cargo in Condensed Polyplexes-Reference-Cited by-同舟云学术

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Serum Nuclease Susceptibility of mRNA Cargo in Condensed Polyplexes

Published:2018-04-19 Issue:6 Volume:15 Page:2268-2276
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Yen Albert¹,Cheng Yilong¹²^ORCID,Sylvestre Meilyn¹,Gustafson Heather H.¹,Puri Sanyogitta³,Pun Suzie H.¹^ORCID

Affiliation:

1. Department of Bioengineering, University of Washington, Seattle, WA 98195, United States

2. Department of Applied Chemistry, School of Science, Xi’an Jiaotong University, Xi’an 710049, P.R. China

3. Advanced Drug Delivery, Pharmaceutical Sciences, IMED Biotech Unit, AstraZeneca, Cambridge CB4 OWG, U.K.

Funder

National Cancer Institute

National Institute of Neurological Disorders and Stroke

Division of Graduate Education

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.8b00134

Reference37 articles.

1. Advances in the delivery of RNA therapeutics: from concept to clinical reality

2. Novel “anti-reverse” cap analogs with superior translational properties

3. Codon Optimality Is a Major Determinant of mRNA Stability

4. Modification of antigen-encoding RNA increases stability, translational efficacy, and T-cell stimulatory capacity of dendritic cells

5. N1-methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice

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