Triphenylphosphonium-modified catiomers enhance in vivo mRNA delivery through stabilized polyion complexation

Author:

Norimatsu Jumpei1,Mizuno Hayato L.2,Watanabe Takayoshi1,Obara Takumi1,Nakakido Makoto13,Tsumoto Kouhei134ORCID,Cabral Horacio15,Kuroda Daisuke6ORCID,Anraku Yasutaka125ORCID

Affiliation:

1. Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan

2. Department of Materials Science and Engineering, School of Materials and Chemical Technology, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550, Japan

3. Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan

4. The Institute of Medical Sciences, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan

5. Innovation Center of NanoMedicine, Kawasaki Institute of Industrial Promotion, 3-25-14 Tonomachi, Kawasaki-ku, Kanagawa 210-0821, Japan

6. Research Center of Drug and Vaccine Development, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan

Abstract

mRNA-based nanocarriers are made of amine-derived cationic materials. Here, we showed the potential of cationic tirphenylphosphonium (TPP) for developing nanocarriers with improved mRNA delivery efficiency.

Funder

Daiichi-Sankyo

Japan Society for the Promotion of Science

Fusion Oriented REsearch for disruptive Science and Technology

JST-Mirai Program

Japan Agency for Medical Research and Development

Publisher

Royal Society of Chemistry (RSC)

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