Beyond cysteine: recent developments in the area of targeted covalent inhibition
Author:
Funder
AstraZeneca
Publisher
Elsevier BV
Subject
Biochemistry,Analytical Chemistry
Reference57 articles.
1. Covalent inhibitors in drug discovery: from accidental discoveries to avoided liabilities and designed therapies;Renato;Drug Discov Today,2015
2. Acetylation of prostaglandin synthase by aspirin;Roth;Proc Natl Acad Sci U S A,1975
3. Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo;Jollow;J Pharmacol Exp Ther,1973
4. The resurgence of covalent drugs;Juswinder;Nat Rev Drug Discov,2011
5. Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor;Finlay;J Med Chem,2014
Cited by 65 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Hit me with your best shot: Integrated hit discovery for the next generation of drug targets;Drug Discovery Today;2024-10
2. Trends in covalent drug discovery: a 2020–23 patent landscape analysis focused on select covalent reacting groups (CRGs) found in FDA-approved drugs;Expert Opinion on Therapeutic Patents;2024-09-11
3. Reactivities of acrylamide warheads toward cysteine targets: a QM/ML approach to covalent inhibitor design;Journal of Computer-Aided Molecular Design;2024-05-01
4. Covalent hits and where to find them;SLAS Discovery;2024-04
5. Molecular Insights into the Impact of Mutations on the Binding Affinity of Targeted Covalent Inhibitors of BTK;The Journal of Physical Chemistry B;2024-03-19
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3