Deamidation of Amino Acids on the Surface of Adeno-Associated Virus Capsids Leads to Charge Heterogeneity and Altered Vector Function-Reference-Cited by-同舟云学术

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Deamidation of Amino Acids on the Surface of Adeno-Associated Virus Capsids Leads to Charge Heterogeneity and Altered Vector Function

Published:2018-12 Issue:12 Volume:26 Page:2848-2862
ISSN:1525-0016
Container-title:Molecular Therapy
language:en
Short-container-title:Molecular Therapy

Author:

Giles April R.,Sims Joshua J.,Turner Kevin B.,Govindasamy Lakshmanan,Alvira Mauricio R.,Lock Martin,Wilson James M.

Funder

National Heart, Lung, and Blood Institute

University of Pennsylvania Perelman School of Medicine

Publisher

Elsevier BV

Subject

Drug Discovery,Pharmacology,Genetics,Molecular Biology,Molecular Medicine

Reference45 articles.

1. The atomic structure of adeno-associated virus (AAV-2), a vector for human gene therapy;Xie;Proc. Natl. Acad. Sci. USA,2002

2. Structure of adeno-associated virus serotype 8, a gene therapy vector;Nam;J. Virol.,2007

3. Structural insights into adeno-associated virus serotype 5;Govindasamy;J. Virol.,2013

4. Characterization of the adeno-associated virus 1 and 6 sialic acid binding site;Huang;J. Virol.,2016

5. The threefold protrusions of adeno-associated virus type 8 are involved in cell surface targeting as well as postattachment processing;Raupp;J. Virol.,2012

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