1,3,4 trisubstituted pyrrolidine CCR5 receptor antagonists bearing 4-aminoheterocycle substituted piperidine side chains-Reference-Cited by-同舟云学术

1,3,4 trisubstituted pyrrolidine CCR5 receptor antagonists bearing 4-aminoheterocycle substituted piperidine side chains

Published:2003-02 Issue:3 Volume:13 Page:427-431
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Willoughby Christopher A,Rosauer Keith G,Hale Jeffery J,Budhu Richard J,Mills Sander G,Chapman Kevin T,MacCoss Malcolm,Malkowitz Lorraine,Springer Martin S,Gould Sandra L,DeMartino Julie A,Siciliano Salvatore J,Cascieri Margaret A,Carella Anthony,Carver Gwen,Holmes Karen,Schleif William A,Danzeisen Renee,Hazuda Daria,Kessler Joseph,Lineberger Janet,Miller Michael,Emini Emilio A

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference15 articles.

1. HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5

2. Identification of a major co-receptor for primary isolates of HIV-1

3. Host factors and the pathogenesis of HIV-induced disease

4. A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity

5. Piperazine-Based CCR5 Antagonists as HIV-1 Inhibitors. II. Discovery of 1-[(2,4-Dimethyl-3-pyridinyl)carbonyl]-4- methyl-4-[3(S)-methyl-4-[1(S)-[4-(trifluoro- methyl)phenyl]ethyl]-1-piperazinyl]- piperidine N1-Oxide (Sch-350634), an Orally Bioavailable, Potent CCR5 Antagonist

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