Piperazine-Based CCR5 Antagonists as HIV-1 Inhibitors. II. Discovery of 1-[(2,4-Dimethyl-3-pyridinyl)carbonyl]-4- methyl-4-[3(S)-methyl-4-[1(S)-[4-(trifluoro- methyl)phenyl]ethyl]-1-piperazinyl]- piperidine N1-Oxide (Sch-350634), an Orally Bioavailable, Potent CCR5 Antagonist-Reference-Cited by-同舟云学术

Piperazine-Based CCR5 Antagonists as HIV-1 Inhibitors. II. Discovery of 1-[(2,4-Dimethyl-3-pyridinyl)carbonyl]-4- methyl-4-[3(S)-methyl-4-[1(S)-[4-(trifluoro- methyl)phenyl]ethyl]-1-piperazinyl]- piperidine N1-Oxide (Sch-350634), an Orally Bioavailable, Potent CCR5 Antagonist

Published:2001-09-07 Issue:21 Volume:44 Page:3343-3346
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Tagat Jayaram R.¹,Steensma Ruo W.¹,McCombie Stuart W.¹,Nazareno Dennis V.¹,Lin Sue-Ing¹,Neustadt Bernard R.¹,Cox Kathleen¹,Xu Serena¹,Wojcik Lisa¹,Murray Michael G.¹,Vantuno Nicole¹,Baroudy Bahige M.¹,Strizki Julie M.¹

Affiliation:

1. Departments of Chemical Research, Drug Metabolism & Pharmacokinetics, and Antiviral Therapy, Schering-Plough Research Institute, K-15-2B-2800, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0155401

Reference17 articles.

1. Fraud and Abuse Law

Cited by 122 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Atroposelective Synthesis of Biaryl N‐Oxides via Cu‐Catalyzed De Novo Heteroaromatic N‐Oxide Ring Formation;Advanced Science;2024-08-09

2. Synthesis of Selenium-Decorated N-Oxide Isoquinolines: Arylseleninic Acids in Selenocyclization Reactions;The Journal of Organic Chemistry;2024-08-01

3. Recent advances in the piperazine based antiviral agents: A remarkable heterocycle for antiviral research;Arabian Journal of Chemistry;2023-12

4. Versatile Therapeutic Values of N‐Containing Heterocycles Benzimidazole, Piperazine and Piperidine Hybrids;ChemistrySelect;2023-10-02

5. Electrochemical C(sp³)–H functionalization of ethersviahydrogen-atom transfer by means of cathodic reduction;Chemical Communications;2023