Mechanism of 17α-Hydroxylase/17,20-Lyase — An initial geometric perspective for the Lyase of the C(17)C(20) bond of C21 steroids
Author:
Publisher
Elsevier BV
Subject
Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry
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1. The mechanism of aromatase — a molecular modelling perspective
2. The involvement of an O2-derived nucleophilic species in acyl–carbon cleavage, catalysed by cytochrome P-45017α: implications for related P-450 catalysed fragmentation reactions
3. Studies on estrogen biosynthesis using radioactive and stable isotopes
4. Molecular modelling of inhibitors of 17α-Hydroxylase — a novel approach
Cited by 4 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Synthesis, Biochemical Evaluation and Rationalisation of the Inhibitory Activity of a Range of Derivatives of 2-imidazol-1-yl-1-phenyl-ethanone as Potential Novel Inhibitors of 17α-hydroxylase/17,20-lyase (P-45017α);Letters in Drug Design & Discovery;2011-07-01
2. Synthesis and biochemical evaluation of a range of (4-substituted phenyl)sulfonate derivatives of 4-hydroxybenzyl imidazole-based compounds as potent inhibitors of 17α-hydroxylase/17,20-lyase (P45017α) derived from rat testicular microsomes;Bioorganic & Medicinal Chemistry Letters;2010-09
3. Synthesis and Biochemical Evaluation of a Range of 2-, 3- and 4-Substituted Derivatives of Benzyl Imidazole-Based Compounds as Probes of the Active Site of 17α-hydroxylase/17,20-Lyase (P45017α);Letters in Drug Design & Discovery;2009-10-01
4. The use of the novel substrate–heme complex approach in the derivation of a representation of the active site of the enzyme complex 17α-hydroxylase and 17,20-lyase;Biochemical and Biophysical Research Communications;2004-04
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