The use of the novel substrate–heme complex approach in the derivation of a representation of the active site of the enzyme complex 17α-hydroxylase and 17,20-lyase-Reference-Cited by-同舟云学术

The use of the novel substrate–heme complex approach in the derivation of a representation of the active site of the enzyme complex 17α-hydroxylase and 17,20-lyase

Published:2004-04 Issue:3 Volume:316 Page:595-598
ISSN:0006-291X
Container-title:Biochemical and Biophysical Research Communications
language:en
Short-container-title:Biochemical and Biophysical Research Communications

Author:

Ahmed Sabbir

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Reference5 articles.

1. Cytochrome P-450: Structure Mechanism and Biochemistry;Ortiz de Montellano,1986

2. Incorporation of label from18O2into acetate during side-chain cleavage catalysed by cytochrome P-45017α(17α-hydroxylase-17,20-lyase)

3. A molecular model for the enzyme cytochrome P45017α, a major target for the chemotherapy of prostatic cancer

4. Mechanism of 17α-Hydroxylase/17,20-Lyase — An initial geometric perspective for the Lyase of the C(17)C(20) bond of C21 steroids

5. Inhibition of testicular 17α-hydroxylase and 17,20-lyase but not 3β-hydroxysteroid dehydrogenase-isomerase or 17β-hydroxysteroid oxidoreductase by ketoconazole and other imidazole drugs

Cited by 11 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Synthesis, Biochemical Evaluation and Rationalisation of the Inhibitory Activity of a Range of Derivatives of 2-imidazol-1-yl-1-phenyl-ethanone as Potential Novel Inhibitors of 17α-hydroxylase/17,20-lyase (P-45017α);Letters in Drug Design & Discovery;2011-07-01

2. Synthesis and biochemical evaluation of a range of (4-substituted phenyl)sulfonate derivatives of 4-hydroxybenzyl imidazole-based compounds as potent inhibitors of 17α-hydroxylase/17,20-lyase (P45017α) derived from rat testicular microsomes;Bioorganic & Medicinal Chemistry Letters;2010-09

3. Synthesis and Biochemical Evaluation of a Range of 2-, 3- and 4-Substituted Derivatives of Benzyl Imidazole-Based Compounds as Probes of the Active Site of 17α-hydroxylase/17,20-Lyase (P45017α);Letters in Drug Design & Discovery;2009-10-01

4. Synthesis and biochemical evaluation of a range of sulfonated derivatives of 4-hydroxybenzyl imidazole as highly potent inhibitors of rat testicular 17α-hydroxylase/17,20-lyase (P-45017α);Bioorganic & Medicinal Chemistry Letters;2009-08

5. 17α-Hydroxylase/17,20-Lyase (P450 ) Inhibitors in the Treatment of Prostate Cancer: A Review;Anti-Cancer Agents in Medicinal Chemistry;2009-07-01