Synthesis and biochemical evaluation of a range of (4-substituted phenyl)sulfonate derivatives of 4-hydroxybenzyl imidazole-based compounds as potent inhibitors of 17α-hydroxylase/17,20-lyase (P45017α) derived from rat testicular microsomes-Reference-Cited by-同舟云学术

Synthesis and biochemical evaluation of a range of (4-substituted phenyl)sulfonate derivatives of 4-hydroxybenzyl imidazole-based compounds as potent inhibitors of 17α-hydroxylase/17,20-lyase (P45017α) derived from rat testicular microsomes

Published:2010-09 Issue:17 Volume:20 Page:5345-5348
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Owen Caroline P.,Shahid Imran,Lee Wai-Yee,Ahmed Sabbir

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference20 articles.

1. Cytochrome P-450: Structure Mechanism and Biochemistry;Ortiz de Montellano,1986

2. Mechanism of 17α-Hydroxylase/17,20-Lyase — An initial geometric perspective for the Lyase of the C(17)C(20) bond of C21 steroids

3. The involvement of an O2-derived nucleophilic species in acyl–carbon cleavage, catalysed by cytochrome P-45017α: implications for related P-450 catalysed fragmentation reactions

4. Response to low-dose ketoconazole and subsequent dose escalation to high-dose ketoconazole in patients with androgen-independent prostate cancer

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2. Determination of 17α-hydroxylase-C17,20-lyase (P45017α) enzyme activities and their inhibition by selected steroidal picolyl and picolinylidene compounds;Acta Biologica Hungarica;2015-03

3. Synthesis and Biochemical Evaluation of a Range of 4-(n-alkanesulfonate) benzyl Imidazole-Based Compounds as Inhibitors of Rat Testicular 17α-hydroxylase/17,20-lyase (P450_17α) in the Treatment of Hormone- Dependent Prostate Cancer;Letters in Drug Design & Discovery;2014-08-08

4. Comprehensive Review in Current Developments of Imidazole-Based Medicinal Chemistry;Medicinal Research Reviews;2013-06-05

5. Synthesis ofO,O'-Dialkyl-α-phenyl-α-phenylsulfonyloxy-methylphosphonate under Ultrasound and Their Antitumor Activity;Chinese Journal of Organic Chemistry;2013