The advantages of describing covalent inhibitor in vitro potencies by IC50 at a fixed time point. IC50 determination of covalent inhibitors provides meaningful data to medicinal chemistry for SAR optimization-Reference-Cited by-同舟云学术

The advantages of describing covalent inhibitor in vitro potencies by IC50 at a fixed time point. IC50 determination of covalent inhibitors provides meaningful data to medicinal chemistry for SAR optimization

Published:2021-01 Issue: Volume:29 Page:115865
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Thorarensen Atli,Balbo Paul,Banker Mary E.,Czerwinski Robert M.,Kuhn Max,Maurer Tristan S.,Telliez Jean-Baptiste^ORCID,Vincent Fabien,Wittwer Arthur J.^ORCID

Funder

Pfizer

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference25 articles.

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5. Bruton's tyrosine kinase inhibitors: approaches to potent and selective inhibition, preclinical and clinical evaluation for inflammatory diseases and B cell malignancies;Lou;J Med Chem.,2012

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