Optimization of purine-nitrile TbcatB inhibitors for use in vivo and evaluation of efficacy in murine models-Reference-Cited by-同舟云学术

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Optimization of purine-nitrile TbcatB inhibitors for use in vivo and evaluation of efficacy in murine models

Published:2010-12 Issue:23 Volume:18 Page:8302-8309
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Mallari Jeremy P.,Zhu Fangyi,Lemoff Andrew,Kaiser Marcel,Lu Min,Brun Reto,Guy R. Kiplin

Funder

American Lebanese Syrian Associated Charities (ALSAC)

St. Jude Children’s Research Hospital (SJCRH)

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference27 articles.

1. WHO Human African Trypanosomiasis Drugs. http://www.who.int/trypanosomiasis_african/drugs/en/.

2. Human African trypanosomiasis of the CNS: current issues and challenges

3. Clinical trials of diamidine in Rhodesian sleeping sickness

4. Efficacy of the Novel Diamidine Compound 2,5-Bis(4-Amidinophenyl)- Furan-Bis- O -Methlylamidoxime (Pafuramidine, DB289) against Trypanosoma brucei rhodesiense Infection in Vervet Monkeys after Oral Administration

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1. Structure-Based Optimization of Quinazolines as Cruzain and TbrCATL Inhibitors;Journal of Medicinal Chemistry;2021-08-30

2. Expression of cysteine proteinases and cystatins in parasites and use of cysteine proteinase inhibitors in parasitic diseases. Part III: Protozoa (3): Kinetoplastids;Parasitologists United Journal;2019-12-01

3. Trypanosomal Cysteine Peptidases: Target Validation and Drug Design Strategies;Comprehensive Analysis of Parasite Biology: From Metabolism to Drug Discovery;2016-07-25

4. Selection of Molecular Targets for Drug Development Against Trypanosomatids;Subcellular Biochemistry;2013-10-11

5. Vinyl Sulfone-Based Peptidomimetics as Anti-Trypanosomal Agents: Design, Synthesis, Biological and Computational Evaluation;Journal of Medicinal Chemistry;2013-09-03

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