Discovery of potent, selective 4-fluoroproline-based thrombin inhibitors with improved metabolic stability-Reference-Cited by-同舟云学术

Discovery of potent, selective 4-fluoroproline-based thrombin inhibitors with improved metabolic stability

Published:2006-10 Issue:20 Volume:14 Page:6900-6916
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Staas Donnette D.,Savage Kelly L.,Sherman Vanessa L.,Shimp Heidi L.,Lyle Terry A.,Tran Lekhanh O.,Wiscount Catherine M.,McMasters Daniel R.,Sanderson Philip E.J.,Williams Peter D.,Lucas Bobby J.,Krueger Julie A.,Dale Lewis S.,White Rebecca B.,Yu Sean,Wong Bradley K.,Kochansky Christopher J.,Reza Anari M.,Yan Youwei,Vacca Joseph P.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference26 articles.

1. Highly active and selective anticoagulants: D-Phe-Pro-Arg-H, a free tripeptide aldehyde prone to spontaneous inactivation, and its stable N-methyl derivative, D-MePhe-Pro-Arg-H

2. D-Phe-Pro-p-Amidinobenzylamine: A potent and highly selective thrombin inhibitor

3. Novel Morpholinone-Based ?-Phe-Pro-Arg Mimics as Potential Thrombin Inhibitors: Design, Synthesis, and X-ray Crystal Structure of an Enzyme Inhibitor Complex

4. Discovery and Evaluation of Potent P1 Aryl Heterocycle-Based Thrombin Inhibitors

5. Metabolism of Fluorine-Containing Drugs

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