Synthesis and evaluation of 1-(cyclopropylmethyl)-4-(4-[ 11 C]methoxyphenyl)-piperidin-1-yl-2-oxo-1,2-dihydropyridine-3-carbonitrile ([ 11 C]CMDC) for PET imaging of metabotropic glutamate receptor 2 in the rat brain-Reference-Cited by-同舟云学术

Synthesis and evaluation of 1-(cyclopropylmethyl)-4-(4-[ 11 C]methoxyphenyl)-piperidin-1-yl-2-oxo-1,2-dihydropyridine-3-carbonitrile ([ 11 C]CMDC) for PET imaging of metabotropic glutamate receptor 2 in the rat brain

Published:2017-02 Issue:3 Volume:25 Page:1014-1021
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Ma Yufei,Kumata Katsushi,Yui Joji,Zhang Yiding,Yamasaki Tomoteru,Hatori Akiko,Fujinaga Masayuki,Nengaki Nobuki,Xie Lin,Wang Hui,Zhang Ming-Rong

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference36 articles.

1. Molecular Diversity of Glutamate Receptors and Implications for Brain Function

2. Ionotropic and metabotropic glutamate receptor structure and pharmacology

3. Metabotropic glutamate receptors: Synaptic transmission, modulation, and plasticity

4. Regulation of Neurotransmitter Release by Metabotropic Glutamate Receptors

5. CNS distribution of metabotropic glutamate 2 and 3 receptors: Transgenic mice and [3H]LY459477 autoradiography

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3. Positron Emission Tomography (PET) Imaging of Metabotropic Glutamate Receptor Subtype 2 (mGlu2) Based on a Negative Allosteric Modulator Radioligand;Neuromethods;2021

4. 3-(Cyclopropylmethyl)-7-((4-(4-[11C]methoxyphenyl)piperidin-1-yl)methyl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine: Synthesis and preliminary evaluation for PET imaging of metabotropic glutamate receptor subtype 2;Bioorganic & Medicinal Chemistry Letters;2020-12

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