Discovery of [<sup>11</sup>C]MK-8056: A Selective PET Imaging Agent for the Study of mGluR<sub>2</sub> Negative Allosteric Modulators-Reference-Cited by-同舟云学术

Discovery of [¹¹C]MK-8056: A Selective PET Imaging Agent for the Study of mGluR₂ Negative Allosteric Modulators

Published:2023-06-13 Issue:7 Volume:14 Page:986-992
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Perkins James J.¹^ORCID,McQuade Paul²,Bungard Christopher J.¹^ORCID,Diamond Tracy L.³,Gantert Liza T.²,Gotter Anthony L.⁴,Hanney Barbara¹,Hills Ivory D.¹,Hurzy Danielle M.¹,Joshi Aniket²,Kern Jonathan T.⁴,Schlegel Kelly-Ann S.¹,Manikowski Jesse J.¹,Meng Zhaoyang¹,O’Brien Julie A.³,Roecker Anthony J.¹^ORCID,Smith Sean M.⁴,Uslaner Jason M.⁴^ORCID,Hostetler Eric²,Meissner Robert S.¹

Affiliation:

1. Departments of Discovery Chemistry, Merck & Co., Inc., 770 Sumneytown Pike, PO Box 4, West Point, Pennsylvania 19486, USA

2. Translational Imaging, Merck & Co., Inc., 770 Sumneytown Pike, PO Box 4, West Point, Pennsylvania 19486, USA

3. Pharmacology, Merck & Co., Inc., 770 Sumneytown Pike, PO Box 4, West Point, Pennsylvania 19486, USA

4. Neuroscience Biology Discovery, Merck & Co., Inc., 770 Sumneytown Pike, PO Box 4, West Point, Pennsylvania 19486, USA

Funder

Merck Sharp and Dohme

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.3c00175

Reference30 articles.

1. Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease

2. Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate Receptors

3. Role of Metabotropic Glutamate Receptors in Neurological Disorders

4. Glutamatergic Approaches to the Treatment of Cognitive and Behavioural Symptoms of Alzheimer’s Disease

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Radiosynthesis and Evaluation of 11C-Labeled Isoindolone-Based Positive Allosteric Modulators for Positron Emission Tomography Imaging of Metabotropic Glutamate Receptor 2;ACS Pharmacology & Translational Science;2024-07-10

2. Autoradiographic labelling of metabotropic glutamate type 2/3 receptors in the hemi-parkinsonian rat brain;Journal of Chemical Neuroanatomy;2024-07

3. Discovery of [11C]MK-8056: A Selective mGluR2 Negative Allosteric Modulator PET Tracer;Synfacts;2024-01-16