An expedient process for reducing the formation of process-related impurities during solid-phase synthesis of potential nucleic acid-based drugs-Reference-Cited by-同舟云学术

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An expedient process for reducing the formation of process-related impurities during solid-phase synthesis of potential nucleic acid-based drugs

Published:2020-11 Issue:22 Volume:28 Page:115779
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Grajkowski Andrzej,Takahashi Mayumi,Cawrse Brian M.,Beaucage Serge L.

Funder

Oak Ridge Institute for Science and Education

U.S. Department of Energy

U.S. Food and Drug Administration

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference14 articles.

1. Integrated safety assessment of 2’-O-methoxyethyl chimeric antisense oligonucleotides in non-human primates and healthy human volunteers;Crooke;Mol Ther,2016

2. Safety of antisense oligonucleotide and siRNA-based therapeutics;Chi;Drug Discov Today,2017

3. An overview of the clinical application of antisense oligonucleotides for RNA-targeting therapies;McClorey;Curr Opin Pharmacol,2015

4. RNA interference-based therapy and its delivery systems;Chen;Cancer Metastasis Rev,2018

5. Sequence identity of the n-1 product of a synthetic oligonucleotide;Temsamani;Nucl Acids Res,1995

Cited by 5 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. From CPG to hybrid support: Review on the approaches in nucleic acids synthesis in various media;Bioorganic Chemistry;2023-11

2. An Alternate Process for the Solid‐Phase Synthesis and Solid‐Phase Purification of Synthetic Nucleic Acid Sequences;Current Protocols;2023-01

3. Use of Arabinonucleosides for Development and Implementation of a Novel 2′‐ O ‐Protecting Group for Efficient Solid‐Phase Synthesis and 2′‐ O ‐Deprotection of RNA Sequences;Current Protocols;2022-01

4. An Improved PEG‐Linked Solid Support for Minimizing Process‐Related Impurities During Solid‐Phase Synthesis of DNA and RNA Sequences;Current Protocols;2021-05

5. Innovative 2′-O-Imino-2-propanoate-Protecting Group for Effective Solid-Phase Synthesis and 2′-O-Deprotection of RNA Sequences;The Journal of Organic Chemistry;2021-03-11

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