Innovative 2′-O-Imino-2-propanoate-Protecting Group for Effective Solid-Phase Synthesis and 2′-O-Deprotection of RNA Sequences-Reference-Cited by-同舟云学术

Innovative 2′-O-Imino-2-propanoate-Protecting Group for Effective Solid-Phase Synthesis and 2′-O-Deprotection of RNA Sequences

Published:2021-03-11 Issue:7 Volume:86 Page:4944-4956
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Takahashi Mayumi¹,Grajkowski Andrzej¹,Cawrse Brian M.¹,Beaucage Serge L.¹^ORCID

Affiliation:

1. Laboratory of Biological Chemistry, Division of Biotechnology Review and Research IV, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, Maryland 20993, United States

Funder

Oak Ridge Institute for Science and Education

U.S. Food and Drug Administration

U.S. Department of Energy

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.0c02773

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1. An overview of the clinical application of antisense oligonucleotides for RNA-targeting therapies

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4. Safety of antisense oligonucleotide and siRNA-based therapeutics

5. An expedient process for reducing the formation of process-related impurities during solid-phase synthesis of potential nucleic acid-based drugs

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