Discovery of novel Flt3 inhibitory chemotypes through extensive ligand-based and new structure-based pharmacophore modelling methods

Author:

Abutayeh Reem Fawaz,Taha Mutasem O.

Funder

Deanship of Academic Research at the University of Jordan

Publisher

Elsevier BV

Subject

Materials Chemistry,Computer Graphics and Computer-Aided Design,Physical and Theoretical Chemistry,Spectroscopy

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3. 4-Amino-6-piperazin-1-yl-pyrimidine-5-carbaldehyde oximes as potent FLT-3 inhibitors;Gaul;Bioorg. Med. Chem. Lett,2007

4. The role of FLT3 in haematopoietic malignancies;Stirewalt;Nat. Rev. Canc.,2003

5. Downstream molecular pathways of FLT3 in the pathogenesis of acute myeloid leukemia: biology and therapeutic implications;Takahashi;J. Hematol. Oncol.,2011

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