Automatic modeling of dynamic drug-hERG channel interactions using three voltage protocols and machine learning techniques: A simulation study
Author:
Publisher
Elsevier BV
Subject
Health Informatics,Computer Science Applications,Software
Reference40 articles.
1. Preclinical torsades-de-pointes screens: advantages and limitations of surrogate and direct approaches in evaluating proarrhythmic risk;Gintant;Pharmacol. Ther.,2008
2. International conference on harmonisation; guidance on S7B nonclinical evaluation of the potential for delayed ventricular repolarization (QT Interval Prolongation) by human pharmaceuticals;Fed. Regist.,2005
3. Rechanneling the cardiac proarrhythmia safety paradigm: a meeting report from the cardiac safety research consortium;Sager;Am. Heart J.,2014
4. Troubleshooting problems with in vitro screening of drugs for QT interval prolongation using HERG K+ channels expressed in mammalian cell lines and xenopus oocytes;Witchel;J. Pharmacol. Toxicol. Methods,2002
5. State dependent dissociation of HERG channel inhibitors;Stork;Br. J. Pharmacol.,2009
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