Experimentally validated modeling of dynamic drug-hERG channel interactions reproducing the binding mechanisms and its importance in action potential duration.

Author:

Escobar FernandoORCID,Friis Soren,Adly Nouran,Brinkwirth Nina,Gomis-Tena JulioORCID,Saiz JavierORCID,Klaerke Dan A.,Stoelzle-Feix Sonja,Romero LuciaORCID

Funder

European Research Council

Government of Spain Ministry of Universities

Government of Valencia

Publisher

Elsevier BV

Reference46 articles.

1. Preclinical Torsades-de-pointes screens: advantages and limitations of surrogate and direct approaches in evaluating Proarrhythmic risk;Gintant;Pharmacol. Ther.,2008

2. International conference on Harmonisation; guidance on s7b nonclinical evaluation of the potential for delayed ventricular repolarization (qt interval prolongation) by human pharmaceuticals;Fed. Regist.,2005

3. Troubleshooting problems with in vitro screening of drugs for QT interval prolongation using herg k+ channels expressed in mammalian cell lines and Xenopus Oocytes;Witchel;J. Pharmacol. Toxicol. Methods.,2002

4. State dependent dissociation of HERG channel inhibitors;Stork;Br. J. Pharmacol.,2007

5. Improving the in silico assessment of proarrhythmia risk by combining hERG (Human Ether-à-go-go-Related Gene) channel-drug binding kinetics and multichannel pharmacology;Li;Circ. Arrhythm. Electrophysiol.,2017

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