R47H TREM2 variant increases risk of typical early‐onset Alzheimer's disease but not of prion or frontotemporal dementia-Reference-Cited by-同舟云学术

R47H TREM2 variant increases risk of typical early‐onset Alzheimer's disease but not of prion or frontotemporal dementia

Published:2014-08-23 Issue:6 Volume:10 Page:602
ISSN:1552-5260
Container-title:Alzheimer's & Dementia
language:en
Short-container-title:Alzheimer's & Dementia

Author:

Slattery Catherine F.¹,Beck Jonathan A.²,Harper Lorna¹,Adamson Gary²,Abdi Zeinab¹,Uphill James²,Campbell Tracy²,Druyeh Ron²,Mahoney Colin J.¹,Rohrer Jonathan D.¹,Kenny Janna²,Lowe Jessica²,Leung Kelvin K.¹,Barnes Josephine¹,Clegg Shona L.¹,Blair Melanie¹,Nicholas Jennifer M.³,Guerreiro Rita J.⁴,Rowe James B.⁵,Ponto Claudia⁶,Zerr Inga⁶,Kretzschmar Hans⁷,Gambetti Pierluigi⁸,Crutch Sebastian J.¹,Warren Jason D.¹,Rossor Martin N.¹,Fox Nick C.¹,Collinge John²,Schott Jonathan M.¹,Mead Simon²

Affiliation:

1. Department of Neurodegenerative DiseaseDementia Research Centre, UCL Institute of NeurologyLondonUK

2. Department of Neurodegenerative DiseaseMRC Prion Unit, UCL Institute of NeurologyLondonUK

3. Department of Medical StatisticsLondon School of Hygiene and Tropical MedicineLondonUK

4. Department of Molecular NeuroscienceUCL Institute of NeurologyLondonUK

5. Department of Clinical NeurosciencesCambridge UniversityUK

6. Department of NeurologyClinical Dementia Center, Georg‐August University GöttingenGöttingenGermany

7. Center for Neuropathology and Prion ResearchLudwig‐Maximilians‐University MunichMunichGermany

8. Department of PathologyCase Western Reserve UniversityClevelandOHUSA

Funder

Medical Research Council

Alzheimer's Research

NIHR Queen Square Dementia Biomedical Research Unit

Leonard Wolfson Experimental Neurology Centre

University College London Hospitals NHS Trust Biomedical Research Centre

MRC

Wellcome Trust

Brain Research Trust

Wellcome Trust Senior Clinical Fellowship

NIHR Cambridge Biomedical Research Centre

Publisher

Wiley

Subject

Psychiatry and Mental health,Cellular and Molecular Neuroscience,Geriatrics and Gerontology,Neurology (clinical),Developmental Neuroscience,Health Policy,Epidemiology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1016/j.jalz.2014.05.1751

Reference39 articles.

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3. Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts

4. Mutations in Two Genes Encoding Different Subunits of a Receptor Signaling Complex Result in an Identical Disease Phenotype

5. The genetic causes of basal ganglia calcification, dementia, and bone cysts: DAP12 and TREM2

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