Design and synthesis of N-alkyldeoxynojirimycin derivatives with improved metabolic stability as inhibitors of BVDV and Tacaribe virus-Reference-Cited by-同舟云学术

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Design and synthesis of N-alkyldeoxynojirimycin derivatives with improved metabolic stability as inhibitors of BVDV and Tacaribe virus

Published:2013-07 Issue:14 Volume:23 Page:4258-4262
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Du Yanming,Ye Hong,Guo Fang,Wang Lijuan,Gill Tina,Khan Noshena,Cuconati Andrea,Guo Ju-Tao,Block Timothy M.,Chang Jinhong,Xu Xiaodong

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference17 articles.

1. ADMET for Medicinal Chemists, A Practical Guide;Tsaioun,2011

2. Ackley, D. C.; Rockich, K. T.; Baker, T. R. In Optimization in Drug Discovery, Yan. Z., Caldwell, G. W., Eds., 2004, p 151.

3. ADME-Guided Design and Synthesis of Aryloxanyl Pyrazolone Derivatives To Block Mutant Superoxide Dismutase 1 (SOD1) Cytotoxicity and Protein Aggregation: Potential Application for the Treatment of Amyotrophic Lateral Sclerosis

4. Metabolic Soft Spot Identification and Compound Optimization in Early Discovery Phases Using MetaSite and LC-MS/MS Validation

5. Current and future trends in the application of HPLC-MS to metabolite-identification studies

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