ADME-Guided Design and Synthesis of Aryloxanyl Pyrazolone Derivatives To Block Mutant Superoxide Dismutase 1 (SOD1) Cytotoxicity and Protein Aggregation: Potential Application for the Treatment of Amyotrophic Lateral Sclerosis-Reference-Cited by-同舟云学术

ADME-Guided Design and Synthesis of Aryloxanyl Pyrazolone Derivatives To Block Mutant Superoxide Dismutase 1 (SOD1) Cytotoxicity and Protein Aggregation: Potential Application for the Treatment of Amyotrophic Lateral Sclerosis

Published:2011-12-22 Issue:1 Volume:55 Page:515-527
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Chen Tian¹,Benmohamed Radhia²,Kim Jinho³⁴,Smith Karen⁵,Amante Daniel³⁴,Morimoto Richard I.⁶,Kirsch Donald R.²,Ferrante Robert J.³⁴,Silverman Richard B.¹⁷

Affiliation:

1. Department of Chemistry, Northwestern University, Evanston, Illinois 60208-3113, United States

2. Cambria Pharmaceuticals, Cambridge, Massachusetts, 02142, United States

3. Departments of Neurological Surgery, Neurology, and Neurobiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, United States

4. Geriatric Research Educational and Clinical Center (00-GR-H), V.A. Pittsburgh Healthcare System, 7180 Highland Drive, Pittsburgh, Pennsylvania 15206, United States

5. Bedford VA Medical Center, 200 Springs Road, Bedford, Massachusetts 01730, United States

6. Department of Molecular Biosciences, Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois 60208-3500, United States

7. Department of Molecular Biosciences, Chemistry of Life Processes Institute, Center for Molecular Innovation and Drug Discovery, Northwestern University, Evanston, Illinois 60208-3113, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm2014277

Reference50 articles.

1. UNRAVELING THE MECHANISMS INVOLVED IN MOTOR NEURON DEGENERATION IN ALS

2. How common are the "common" neurologic disorders?

3. Ethnic variation in the incidence of ALS

4. Excess incidence of ALS in young Gulf War veterans

5. Occurrence of amyotrophic lateral sclerosis among Gulf War veterans

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