Metabolic Soft Spot Identification and Compound Optimization in Early Discovery Phases Using MetaSite and LC-MS/MS Validation
Author:
Affiliation:
1. Novartis Institutes for BioMedical Research, Metabolism and Pharmacokinetics, Postfach, CH-4002, Basel, Switzerland
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm8008663
Reference22 articles.
1. DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
2. Use of In Vitro and In Vivo Data to Estimate the Likelihood of Metabolic Pharmacokinetic Interactions
3. Managing the drug discovery/development interface
4. Role of drug metabolism in drug discovery and development
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