The identification of novel orally active mGluR5 antagonist GSK2210875-Reference-Cited by-同舟云学术

The identification of novel orally active mGluR5 antagonist GSK2210875

Published:2010-12 Issue:24 Volume:20 Page:7521-7524
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Pilla Maria,Andreoli Michela,Tessari Michela,Delle-Fratte Sonia,Roth Adelheid,Butler Sharon,Brown Fiona,Shah Parita,Bettini Ezio,Cavallini Palmina,Benedetti Roberto,Minick Doug,Smith Paul,Tehan Ben,D’Alessandro Pier,Lorthioir Olivier,Ball Catherine,Garzya Vincenzo,Goodacre Caroline,Watson Stephen

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference13 articles.

1. mGlu5 receptor antagonists and their therapeutic potential

2. Reported for example at 6th International Symposium on metabatropic Glutamate Receptors, Taormina, Italy, September, 2008.

3. 3-[3-Fluoro-5-(5-pyridin-2-yl-2H-tetrazol-2-yl)phenyl]-4-methylpyridine: a highly potent and orally bioavailable metabotropic glutamate subtype 5 (mGlu5) receptor antagonist

4. Fenobam: A Clinically Validated Nonbenzodiazepine Anxiolytic Is a Potent, Selective, and Noncompetitive mGlu5 Receptor Antagonist with Inverse Agonist Activity

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